Assessment and implication of prognostic imbalance in randomized controlled trials with a binary outcome--a simulation study.

Assessment and implication of prognostic imbalance in randomized controlled trials with a binary outcome--a simulation study.

Chance imbalance in baseline prognosis of a randomized controlled trial can lead to over or underestimation of treatment effects, particularly in trials with small sample sizes. Our study aimed to (1) evaluate the probability of imbalance in a binary prognostic factor (PF) between two treatment arms...

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Bibliographic Details
Main Authors: Rong Chu, Stephen D Walter, Gordon Guyatt, P J Devereaux, Michael Walsh, Kristian Thorlund, Lehana Thabane
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3358303?pdf=render

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http://europepmc.org/articles/PMC3358303?pdf=render

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