JAK inhibition ameliorates bone destruction by simultaneously targeting mature osteoclasts and their precursors

JAK inhibition ameliorates bone destruction by simultaneously targeting mature osteoclasts and their precursors

Abstract Background Rheumatoid arthritis (RA) is characterized by chronic inflammation and resultant cartilage/bone destruction because of aberrantly activated osteoclasts. Recently, novel treatments with several Janus kinase (JAK) inhibitors have been shown to successfully ameliorate arthritis-rela...

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Bibliographic Details
Main Authors: Shinya Yari, Junichi Kikuta, Hotaka Shigyo, Yu Miyamoto, Daisuke Okuzaki, Yuki Furusawa, Masafumi Minoshima, Kazuya Kikuchi, Masaru Ishii
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Inflammation and Regeneration
Subjects:
JAK inhibitor
Osteoclast
Intravital imaging
Inflammatory bone destruction
Cell migration
Chemokine
Online Access:https://doi.org/10.1186/s41232-023-00268-4

Internet

https://doi.org/10.1186/s41232-023-00268-4

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