CCN2/CTGF—A Modulator of the Optic Nerve Head Astrocyte

CCN2/CTGF—A Modulator of the Optic Nerve Head Astrocyte

In primary open-angle glaucoma (POAG), a neurodegenerative disease of the optic nerve (ON) and leading cause of blindness, the optic nerve head (ONH) undergoes marked structural extracellular matrix (ECM) changes, which contribute to its permanent deformation and to degeneration of ON axons. The rem...

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Bibliographic Details
Main Authors: Andrea E. Dillinger, Gregor R. Weber, Matthias Mayer, Magdalena Schneider, Corinna Göppner, Andreas Ohlmann, Mikhail Shamonin, Gareth J. Monkman, Rudolf Fuchshofer
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
glaucoma
optic nerve
growth factors
astrocytes
stiffness
extracellar matrix
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.864433/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2022.864433/full

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