Tissue-Specific Vulnerability to Apoptosis in Machado-Joseph Disease

Tissue-Specific Vulnerability to Apoptosis in Machado-Joseph Disease

Machado-Joseph disease (MJD) is a dominant neurodegenerative disease caused by an expanded CAG repeat in the <i>ATXN3</i> gene encoding the ataxin-3 protein. Several cellular processes, including transcription and apoptosis, are disrupted in MJD. To gain further insights into the extent...

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Bibliographic Details
Main Authors: Ana F. Ferreira, Mafalda Raposo, Emily D. Shaw, Naila S. Ashraf, Filipa Medeiros, Maria de Fátima Brilhante, Matthew Perkins, João Vasconcelos, Teresa Kay, Maria do Carmo Costa, Manuela Lima
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Cells
Subjects:
polyglutamine disease
spinocerebellar ataxia type 3
SCA3
MJD
ATXN3
ataxin-3
Online Access:https://www.mdpi.com/2073-4409/12/10/1404

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https://www.mdpi.com/2073-4409/12/10/1404

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