Medium-Chain Length Fatty Acids Enhance Aβ Degradation by Affecting Insulin-Degrading Enzyme

Medium-Chain Length Fatty Acids Enhance Aβ Degradation by Affecting Insulin-Degrading Enzyme

The accumulation of amyloid β-protein (Aβ) is one of the major pathological hallmarks of Alzheimer’s disease. Insulin-degrading enzyme (IDE), a zinc-metalloprotease, is a key enzyme involved in Aβ degradation, which, in addition to Aβ production, is critical for Aβ homeostasis. Here, we demonstrate...

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Bibliographic Details
Main Authors: Janine Mett, Anna A. Lauer, Daniel Janitschke, Lea V. Griebsch, Elena L. Theiss, Heike S. Grimm, Hennariikka Koivisto, Heikki Tanila, Tobias Hartmann, Marcus O. W. Grimm
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Cells
Subjects:
Aβ degradation
insulin-degrading enzyme
Alzheimer´s disease
fatty acids
medium-chain fatty acids
lauric acid
Online Access:https://www.mdpi.com/2073-4409/10/11/2941

Internet

https://www.mdpi.com/2073-4409/10/11/2941

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