The c-Myc/TBX3 Axis Promotes Cellular Transformation of Sarcoma-Initiating Cells

The c-Myc/TBX3 Axis Promotes Cellular Transformation of Sarcoma-Initiating Cells

Sarcomas are highly aggressive cancers of mesenchymal origin whose clinical management is highly complex. This is partly due to a lack of understanding of the molecular mechanisms underpinning the transformation of mesenchymal stromal/stem cells (MSCs) which are presumed to be the sarcoma-initiating...

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Bibliographic Details
Main Authors: Victoria Damerell, Melvin Anyasi Ambele, Shanel Salisbury, Alexis Neumann-Mufweba, Chrisna Durandt, Michael Sean Pepper, Sharon Prince
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Oncology
Subjects:
mesenchymal stromal/stem cells (MSCs)
sarcoma
c-Myc
TBX3
oncogene
tumorigenesis
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.801691/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.801691/full

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