Circulating succinate-modifying metabolites accurately classify and reflect the status of fumarate hydratase–deficient renal cell carcinoma
Germline or somatic loss-of-function mutations of fumarate hydratase (FH) predispose patients to an aggressive form of renal cell carcinoma (RCC). Since other than tumor resection there is no effective therapy for metastatic FH-deficient RCC, an accurate method for early diagnosis is needed. Althoug...
| Päätekijät: | , , , , , , , , , , , , , , |
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| Aineistotyyppi: | Artikkeli |
| Kieli: | English |
| Julkaistu: |
American Society for Clinical Investigation
2023-06-01
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| Sarja: | The Journal of Clinical Investigation |
| Aiheet: | |
| Linkit: | https://doi.org/10.1172/JCI165028 |