Activation of cAMP (EPAC2) signaling pathway promotes hepatocyte attachment

Abstract Primary Human Hepatocyte (PHH) remains undefeated as the gold standard in hepatic studies. Despite its valuable properties, partial attachment loss due to the extraction process and cryopreservation remained the main hurdle in its application. We hypothesized that we could overcome the loss...

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Bibliographic Details
Main Authors: Grace Aprilia Helena, Teruhiko Watanabe, Yusuke Kato, Nobuaki Shiraki, Shoen Kume
Format: Article
Language:English
Published: Nature Portfolio 2023-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-39712-3