Fenofibrate Decreases Ethanol-Induced Neuroinflammation and Oxidative Stress and Reduces Alcohol Relapse in Rats by a PPAR-α-Dependent Mechanism

Fenofibrate Decreases Ethanol-Induced Neuroinflammation and Oxidative Stress and Reduces Alcohol Relapse in Rats by a PPAR-α-Dependent Mechanism

High ethanol consumption triggers neuroinflammation, implicated in sustaining chronic alcohol use. This inflammation boosts glutamate, prompting dopamine release in reward centers, driving prolonged drinking and relapse. Fibrate drugs, activating peroxisome proliferator-activated receptor alpha (PPA...

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Bibliographic Details
Main Authors: Cristina Ibáñez, Tirso Acuña, María Elena Quintanilla, Diliana Pérez-Reytor, Paola Morales, Eduardo Karahanian
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Antioxidants
Subjects:
alcohol use disorder
alcoholism
fibrates
neuroinflammation
PPAR alpha
Online Access:https://www.mdpi.com/2076-3921/12/9/1758

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https://www.mdpi.com/2076-3921/12/9/1758

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