Evaluation of the effect of perioperative administration of S(+)-ketamine hydrochloride injection for postoperative acute pain in children: study protocol for a prospective, multicenter, randomized, open-label, parallel-group, pragmatic clinical trial

Evaluation of the effect of perioperative administration of S(+)-ketamine hydrochloride injection for postoperative acute pain in children: study protocol for a prospective, multicenter, randomized, open-label, parallel-group, pragmatic clinical trial

Abstract Background Inadequate postoperative pain management increases the risk of adverse events after the surgery and aggressive perioperative pain prevention has both short-term and long-term benefits. S(+)-ketamine is an N-methyl-D-aspartic acid (NMDA) receptor antagonist with a strong analgesic...

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Bibliographic Details
Main Authors: Hong Wang, Chongyang Duan, Jianmin Zhang, Shuangquan Qu, Ying Sun, Lizhi Zhou, Lujia Yang, Chen Lan, Weidong Mi, Pingyan Chen
Format: Article
Language:English
Published: BMC 2022-07-01
Series:Trials
Subjects:
Postoperative pain
Acute pain
Children
Perioperative period
Anesthesia
Analgesia
Online Access:https://doi.org/10.1186/s13063-022-06534-z

Internet

https://doi.org/10.1186/s13063-022-06534-z

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