Screening approaches for the identification of Nrf2-Keap1 protein-protein interaction inhibitors targeting hot spot residues

Screening approaches for the identification of Nrf2-Keap1 protein-protein interaction inhibitors targeting hot spot residues

Protein-protein interactions (PPIs) play a crucial role in most biological processes and are important targets in the development of therapeutic agents. However, small molecule drug discovery that targets PPIs remains very challenging. Targeting hot spot residues is considered the best option for in...

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Bibliographic Details
Main Authors: Wataru Asano, Rie Hantani, Toru Uhara, François Debaene, Akihiro Nomura, Keishi Yamaguchi, Tsuyoshi Adachi, Kazuki Otake, Kazuhito Harada, Yoshiji Hantani
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:SLAS Discovery
Subjects:
Keap1
Nrf2
Biophysical assay
Protein-protein interaction
Hot spot
Online Access:http://www.sciencedirect.com/science/article/pii/S2472555223000795

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http://www.sciencedirect.com/science/article/pii/S2472555223000795

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