Drug reinforcement impairs cognitive flexibility by inhibiting striatal cholinergic neurons

Drug reinforcement impairs cognitive flexibility by inhibiting striatal cholinergic neurons

Abstract Addictive substance use impairs cognitive flexibility, with unclear underlying mechanisms. The reinforcement of substance use is mediated by the striatal direct-pathway medium spiny neurons (dMSNs) that project to the substantia nigra pars reticulata (SNr). Cognitive flexibility is mediated...

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Bibliographic Details
Main Authors: Himanshu Gangal, Xueyi Xie, Zhenbo Huang, Yifeng Cheng, Xuehua Wang, Jiayi Lu, Xiaowen Zhuang, Amanda Essoh, Yufei Huang, Ruifeng Chen, Laura N. Smith, Rachel J. Smith, Jun Wang
Format: Article
Language:English
Published: Nature Portfolio 2023-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-39623-x

Internet

https://doi.org/10.1038/s41467-023-39623-x

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