PK/PD integration for intramuscular dose determination of intramuscular sodium cloxacillin for infections caused by Staphylococcus spp in goat

PK/PD integration for intramuscular dose determination of intramuscular sodium cloxacillin for infections caused by Staphylococcus spp in goat

ABSTRACT This study aims to determine therapeutic protocols of intramuscular sodium cloxacillin (IM) in goats with potential antibacterial effects against Staphylococcus spp. We constructed a pharmacokinetic (PK) model of IM, followed by a pharmacokinetic/pharmacodynamic integration (PK/PD). Simulat...

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Bibliographic Details
Main Authors: L.A. Felix, L.W.F. Gonzaga, B.C.F. Soares, G. Suárez, H.M. Brandão, P.Y. Faccioli-Martins, M. Ferrante
Format: Article
Language:English
Published: Universidade Federal de Minas Gerais 2023-11-01
Series:Arquivo Brasileiro de Medicina Veterinária e Zootecnia
Subjects:
antibiotic therapy
Monte Carlo simulation
pharmacometrics
sepsis
translational model
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352023000601087&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352023000601087&lng=en&tlng=en

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