The Influence of <i>APOE</i> Genotype, DHA, and Flavanol Intervention on Brain DHA and Lipidomics Profile in Aged Transgenic Mice

The Influence of <i>APOE</i> Genotype, DHA, and Flavanol Intervention on Brain DHA and Lipidomics Profile in Aged Transgenic Mice

The apolipoprotein E4 (<i>APOE4</i>) genotype is predictive of Alzheimer’s disease (AD). The brain is highly enriched with the omega-3 polyunsaturated fatty acid (n3-PUFA), docosahexaenoic acid (DHA). DHA’s metabolism is defective in <i>APOE4</i> carriers. Flavanol intake can...

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Bibliographic Details
Main Authors: Anneloes Martinsen, Rasha N. M. Saleh, Raphael Chouinard-Watkins, Richard Bazinet, Glenn Harden, James Dick, Noemi Tejera, Matthew G. Pontifex, David Vauzour, Anne-Marie Minihane
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Nutrients
Subjects:
Alzheimer’s disease
apolipoprotein E
docosahexaenoic acid
brain
flavonoids
phospholipids
Online Access:https://www.mdpi.com/2072-6643/15/9/2032

Internet

https://www.mdpi.com/2072-6643/15/9/2032

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