Identification of regions critical for the integrity of the TSC1-TSC2-TBC1D7 complex.

Identification of regions critical for the integrity of the TSC1-TSC2-TBC1D7 complex.

The TSC1-TSC2-TBC1D7 complex is an important negative regulator of the mechanistic target of rapamycin complex 1 that controls cell growth in response to environmental cues. Inactivating TSC1 and TSC2 mutations cause tuberous sclerosis complex (TSC), an autosomal dominant disorder characterised by t...

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Bibliographic Details
Main Authors: Arthur Jorge Santiago Lima, Marianne Hoogeveen-Westerveld, Akio Nakashima, Anneke Maat-Kievit, Ans van den Ouweland, Dicky Halley, Ushio Kikkawa, Mark Nellist
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0093940&type=printable

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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0093940&type=printable

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