Supramolecular approaches for insulin stabilization without prolonged duration of action

Supramolecular approaches for insulin stabilization without prolonged duration of action

Aggregation represents a significant challenge for the long-term formulation stability of insulin therapeutics. The supramolecular PEGylation of insulin with conjugates of cucurbit[7]uril and polyethylene glycol (CB[7]‒PEG) has been shown to stabilize insulin formulations by reducing aggregation pro...

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Detalhes bibliográficos
Main Authors: Rolande Meudom, Yanxian Zhang, Michael A. VandenBerg, Lei Zou, Yi Wolf Zhang, Matthew J. Webber, Danny Hung-Chieh Chou
Formato: Artigo
Idioma:English
Publicado em: Elsevier 2023-05-01
Colecção:Acta Pharmaceutica Sinica B
Assuntos:
Diabetes mellitus
Insulin aggregation
Supramolecular PEGylation
Selective N-Terminal modification
N-terminal acid-modified insulin
Subcutaneous depot
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2211383523000084

Internet

http://www.sciencedirect.com/science/article/pii/S2211383523000084

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