Neuroprotective Effect of Fisetin Through Suppression of IL-1R/TLR Axis and Apoptosis in Pentylenetetrazole-Induced Kindling in Mice

Neuroprotective Effect of Fisetin Through Suppression of IL-1R/TLR Axis and Apoptosis in Pentylenetetrazole-Induced Kindling in Mice

Epilepsy is a complex neurological disorder, characterized by frequent electrical activity in brain regions. Inflammation and apoptosis cascade activation are serious neurological sequelae during seizures. Fisetin (3, 3′,4′,7-tetrahydroxyflavone), a flavonoid molecule, is considered for its effectiv...

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Bibliographic Details
Main Authors: Saima Khatoon, Nidhi Bharal Agarwal, Mohammed Samim, Ozair Alam
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Neurology
Subjects:
pentylenetetrazole
fisetin
interleukin
toll like receptor-4
caspase-3
epilepsy
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2021.689069/full

Internet

https://www.frontiersin.org/articles/10.3389/fneur.2021.689069/full

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