Pharmacophore anchor models of flaviviral NS3 proteases lead to drug repurposing for DENV infection

Pharmacophore anchor models of flaviviral NS3 proteases lead to drug repurposing for DENV infection

Abstract Background Viruses of the flaviviridae family are responsible for some of the major infectious viral diseases around the world and there is an urgent need for drug development for these diseases. Most of the virtual screening methods in flaviviral drug discovery suffer from a low hit rate,...

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Bibliographic Details
Main Authors: Nikhil Pathak, Mei-Ling Lai, Wen-Yu Chen, Betty-Wu Hsieh, Guann-Yi Yu, Jinn-Moon Yang
Format: Article
Language:English
Published: BMC 2017-12-01
Series:BMC Bioinformatics
Subjects:
Flaviviral NS3 proteases
DENV NS3 protease
Pharmacophore anchor models
Core and specific anchors
Integrated anchor-based virtual screening
Online Access:http://link.springer.com/article/10.1186/s12859-017-1957-5

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http://link.springer.com/article/10.1186/s12859-017-1957-5

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