TGF-β and SHH Regulate Pluripotent Stem Cell Differentiation into Brain Microvascular Endothelial Cells in Generating an In Vitro Blood–Brain Barrier Model

TGF-β and SHH Regulate Pluripotent Stem Cell Differentiation into Brain Microvascular Endothelial Cells in Generating an In Vitro Blood–Brain Barrier Model

Blood–brain barrier (BBB) models are important tools for studying CNS drug delivery, brain development, and brain disease. In vitro BBB models have been obtained from animals and immortalized cell lines; however, brain microvascular endothelial cells (BMECs) derived from them have several limitation...

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Bibliographic Details
Main Authors: Na Geum Lee, Mi-Hee Lim, Jongjin Park, In Cheul Jeung, Byungtae Hwang, Jangwook Lee, Jong-Gil Park, Mi-Young Son, Baek Soo Han, Sung-Jin Yoon, Seon-Jin Lee, Young-Jun Park, Jae Ho Kim, Nam-Kyung Lee, Sang Chul Lee, Jeong-Ki Min
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Bioengineering
Subjects:
human pluripotent stem cells
brain microvascular endothelial cells
blood–brain barrier
differentiation
sonic hedgehog
Online Access:https://www.mdpi.com/2306-5354/10/10/1132

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https://www.mdpi.com/2306-5354/10/10/1132

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