Effects of high‐fat diet on nutrient metabolism and cognitive functions in young APPKINL‐G‐F/NL‐G‐F mice

Effects of high‐fat diet on nutrient metabolism and cognitive functions in young APPKINL‐G‐F/NL‐G‐F mice

Abstract Aim Type 2 diabetes mellitus (T2DM) is an increased risk factor for Alzheimer’s disease (AD); however, the relationship between the 2 conditions is controversial. High‐fat diet (HFD) causes cognitive impairment with/without Aβ accumulation in middle‐aged or aged transgenic (Tg) and knock‐in...

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Bibliographic Details
Main Authors: Wei Wang, Daisuke Tanokashira, Yudai Shibayama, Ryuhei Tsuji, Megumi Maruyama, Chiemi Kuroiwa, Takashi Saito, Takaomi C. Saido, Akiko Taguchi
Format: Article
Language:English
Published: Wiley 2022-09-01
Series:Neuropsychopharmacology Reports
Subjects:
Alzheimer’s disease
cognitive function
high‐fat diet
hippocampus
insulin receptor substrate 1
knock‐in mouse model
Online Access:https://doi.org/10.1002/npr2.12257

Internet

https://doi.org/10.1002/npr2.12257

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