Role of cross-reactivity in cellular immune targeting of influenza A M158-66 variant peptide epitopes

The immunologic significance of cross-reactivity of TCR recognition of peptide:MHC complexes is still poorly understood. We have described TCR cross-reactivity in a system involving polyclonal CD8 T cell recognition of the well characterized influenza viral M158-66 epitope. While M158-66 is generall...

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Bibliographic Details
Main Authors: Galina V. Petrova, Yuri N. Naumov, Elena N. Naumova, Jack Gorski
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Immunology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.956103/full