HDAC Inhibition Counteracts Metastatic Re-Activation of Prostate Cancer Cells Induced by Chronic mTOR Suppression

HDAC Inhibition Counteracts Metastatic Re-Activation of Prostate Cancer Cells Induced by Chronic mTOR Suppression

This study was designed to investigate whether epigenetic modulation by histone deacetylase (HDAC) inhibition might circumvent resistance towards the mechanistic target of rapamycin (mTOR) inhibitor temsirolimus in a prostate cancer cell model. Parental (par) and temsirolimus-resistant (res) PC3 pro...

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Bibliographic Details
Main Authors: Jasmina Makarević, Jochen Rutz, Eva Juengel, Sebastian Maxeiner, Jens Mani, Stefan Vallo, Igor Tsaur, Frederik Roos, Felix K.-H. Chun, Roman A. Blaheta
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:Cells
Subjects:
mTOR
histone deacetylase
prostate cancer
integrins
adhesion
invasion
Online Access:http://www.mdpi.com/2073-4409/7/9/129

Internet

http://www.mdpi.com/2073-4409/7/9/129

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