MANF regulates neuronal survival and UPR through its ER-located receptor IRE1α

MANF regulates neuronal survival and UPR through its ER-located receptor IRE1α

Summary: Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an endoplasmic reticulum (ER)-located protein with cytoprotective effects in neurons and pancreatic β cells in vitro and in models of neurodegeneration and diabetes in vivo. However, the exact mode of MANF action has remained elu...

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Bibliographic Details
Main Authors: Vera Kovaleva, Li-Ying Yu, Larisa Ivanova, Olesya Shpironok, Jinhan Nam, Ave Eesmaa, Esa-Pekka Kumpula, Sven Sakson, Urve Toots, Mart Ustav, Juha T. Huiskonen, Merja H. Voutilainen, Päivi Lindholm, Mati Karelson, Mart Saarma
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:Cell Reports
Subjects:
CP: Neuroscience
CP: Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723000773

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http://www.sciencedirect.com/science/article/pii/S2211124723000773

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