EFFECT OF PEPTIDE INTERVENTION BASED ON THE CARBOXYL-TERMINAL 375STANT379 PHOSPHORYLATION SITE OF μ OPIOID RECEPTOR ON THE MORPHINE-MEDIATED RECEPTOR DOWNSTREAM SIGNALING PATHWAY

EFFECT OF PEPTIDE INTERVENTION BASED ON THE CARBOXYL-TERMINAL 375STANT379 PHOSPHORYLATION SITE OF μ OPIOID RECEPTOR ON THE MORPHINE-MEDIATED RECEPTOR DOWNSTREAM SIGNALING PATHWAY

Objective To study the effect of peptide TAT-Q368-T379 intervention based on the carboxyl-terminal 375STANT379 phosphorylation site of μ opioid receptor (MOR) on the MOR downstream signaling pathway. Methods HEK-293 cells co-transfected with HA-MOR plasmids and pGloSensorTM-22F plasmids were divided...

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Bibliographic Details
Main Author: LI Xiaoyan, ZHOU Xiaohui, DONG He, DONG Mingxin
Format: Article
Language:zho
Published: Editorial Office of Journal of Precision Medicine 2023-08-01
Series:精准医学杂志
Subjects:
receptors, opioid, mu|phosphorylation|morphine|peptides|signal transduction|gtp-binding proteins|beta-arrestin 2
Online Access:https://jpmed.qdu.edu.cn/fileup/2096-529X/PDF/202304006.pdf

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https://jpmed.qdu.edu.cn/fileup/2096-529X/PDF/202304006.pdf

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