Multitasking Pharmacophores Support Cabotegravir-Based Long-Acting HIV Pre-Exposure Prophylaxis (PrEP)

Multitasking Pharmacophores Support Cabotegravir-Based Long-Acting HIV Pre-Exposure Prophylaxis (PrEP)

Cabotegravir is an integrase strand transfer inhibitor (INSTI) for HIV treatment and prevention. Cabotegravir-based long-acting pre-exposure prophylaxis (PrEP) presents an emerging paradigm for infectious disease control. In this scheme, a combination of a high efficacy and low solubility of anti-in...

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Bibliographic Details
Main Authors: Zheng Wan, Man Shi, Yanqing Gong, Massimo Lucci, Jinjin Li, Jiahai Zhou, Xiao-Liang Yang, Moreno Lelli, Xiao He, Jiafei Mao
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Molecules
Subjects:
HIV pre-exposure prophylaxis
cabotegravir
X-ray diffraction
NMR
DFT
AF-QM/MM
Online Access:https://www.mdpi.com/1420-3049/29/2/376

Internet

https://www.mdpi.com/1420-3049/29/2/376

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