Novel Benzimidazole-Based Compounds as Antimicrobials: Synthesis, Molecular Docking, Molecular Dynamics and in silico ADME Profile Studies

Novel Benzimidazole-Based Compounds as Antimicrobials: Synthesis, Molecular Docking, Molecular Dynamics and in silico ADME Profile Studies

Some novel benzimidazole derivatives were synthesized and their antimicrobial activities were evaluated. Compounds 3a and 3b exhibited excellent antibacterial activity with MIC values <4 µg/mL against Staphylococcus aureus ATCC 29213 (MSSA) and Staphylococcus aureus ATCC 43300 (MRSA). Molecular d...

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Bibliographic Details
Main Authors: Elif Yeşilçayır, İsmail Çelik, Hasan Tahsin Şen, Suna Sibel Gürpınar, Müjde Eryılmaz, Gülgün Kilcigil
Format: Article
Language:English
Published: Slovenian Chemical Society 2022-06-01
Series:Acta Chimica Slovenica
Subjects:
benzimidazole
antimicrobial activity
molecular docking
molecular dynamics
Online Access:https://journals.matheo.si/index.php/ACSi/article/view/7314

Internet

https://journals.matheo.si/index.php/ACSi/article/view/7314

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