An mRNA-Based Multiple Antigenic Gene Expression System Delivered by Engineered <i>Salmonella</i> for Severe Fever with Thrombocytopenia Syndrome and Assessment of Its Immunogenicity and Protection Using a Human DC-SIGN-Transduced Mouse Model

An mRNA-Based Multiple Antigenic Gene Expression System Delivered by Engineered <i>Salmonella</i> for Severe Fever with Thrombocytopenia Syndrome and Assessment of Its Immunogenicity and Protection Using a Human DC-SIGN-Transduced Mouse Model

Currently, there are no commercial vaccines or therapeutics against severe fever with thrombocytopenia syndrome (SFTS) virus. This study explored an engineered Salmonella as a vaccine carrier to deliver a eukaryotic self-mRNA replicating vector, pJHL204. This vector expresses multiple SFTS virus ant...

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Bibliographic Details
Main Authors: Ji-Young Park, Chamith Hewawaduge, Chandran Sivasankar, Khristine Kaith S. Lloren, Byungkwan Oh, Mi Young So, John Hwa Lee
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Pharmaceutics
Subjects:
Salmonella delivery
vaccine
SFTS
viral protein
hDC-SIGN
Online Access:https://www.mdpi.com/1999-4923/15/5/1339

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https://www.mdpi.com/1999-4923/15/5/1339

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