Application of ddPCR in detection of the status and abundance of EGFR T790M mutation in the plasma samples of non-small cell lung cancer patients

Application of ddPCR in detection of the status and abundance of EGFR T790M mutation in the plasma samples of non-small cell lung cancer patients

Background/ObjectiveThe third-generation epidermal growth factor receptor (EGFR) -tyrosine kinase inhibitor (TKIs), such as osimertinib, designed for targeting the acquired drug-resistant mutation of EGFR T790M, was approved as the first-line therapy for advanced EGFR-mutated non-small cell lung can...

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Bibliographic Details
Main Authors: Hui Zhang, Yi Hu, Yan Wang, Xia Song, Ying Hu, Li Ma, Xinjie Yang, Kun Li, Na Qin, Jinghui Wang, Jialin Lv, Xi Li, Xinyong Zhang, Quan Zhang, Yuhua Wu, Guangyin Yao, Shucai Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Oncology
Subjects:
EGFR T790M
ddPCR
NGS
plasma
third-generation EGFR-TKIs
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.942123/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.942123/full

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