Alamandine/MrgD axis prevents TGF-β1-mediated fibroblast activation via regulation of aerobic glycolysis and mitophagy

Alamandine/MrgD axis prevents TGF-β1-mediated fibroblast activation via regulation of aerobic glycolysis and mitophagy

Abstract Background Idiopathic pulmonary fibrosis is a chronic progressive, lethal disease in which ectopic lung fibroblast (LF) activation plays a vital part. We have previously shown that alamandine (ALA) exerts anti-fibrosis effects via the MAS-related G-protein coupled receptor D (MrgD). Here, w...

Full description

Bibliographic Details
Main Authors: Wei Wang, Yue Zhang, Wenhui Huang, Yafei Yuan, Qiaohui Hong, Zhanzhan Xie, Lijuan Li, Yixin Chen, Xu Li, Ying Meng
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Journal of Translational Medicine
Subjects:
Pulmonary fibrosis
Fibroblast activation
Alamandine/MrgD axis
Mitophagy
Aerobic glycolysis
Online Access:https://doi.org/10.1186/s12967-022-03837-2

Internet

https://doi.org/10.1186/s12967-022-03837-2

Similar Items