Use of Synonymous Deoptimization to Derive Modified Live Attenuated Strains of Foot and Mouth Disease Virus

Use of Synonymous Deoptimization to Derive Modified Live Attenuated Strains of Foot and Mouth Disease Virus

Foot-and-mouth disease (FMD) is one of the most economically important viral diseases that can affect livestock. In the last 70 years, use of an inactivated whole antigen vaccine has contributed to the eradication of disease from many developed nations. However, recent outbreaks in Europe and Easter...

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Bibliographic Details
Main Authors: Fayna Diaz-San Segundo, Gisselle N. Medina, Edward Spinard, Anna Kloc, Elizabeth Ramirez-Medina, Paul Azzinaro, Steffen Mueller, Elizabeth Rieder, Teresa de los Santos
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Microbiology
Subjects:
FMDV
synonymous deoptimization
codon bias
vaccine
attenuation
FMD
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2020.610286/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2020.610286/full

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