Nitric Oxide Resistance in <i>Leishmania</i> (<i>Viannia</i>) <i>braziliensis</i> Involves Regulation of Glucose Consumption, Glutathione Metabolism and Abundance of Pentose Phosphate Pathway Enzymes

Nitric Oxide Resistance in <i>Leishmania</i> (<i>Viannia</i>) <i>braziliensis</i> Involves Regulation of Glucose Consumption, Glutathione Metabolism and Abundance of Pentose Phosphate Pathway Enzymes

In American Tegumentary Leishmaniasis production of cytokines, reactive oxygen species and nitric oxide (NO) by host macrophages normally lead to parasite death. However, some <i>Leishmania braziliensis</i> strains exhibit natural NO resistance. NO-resistant strains cause more lesions an...

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Bibliographic Details
Main Authors: Nathalia Pinho, Ana Cristina Bombaça, Jacek R. Wiśniewski, Geovane Dias-Lopes, Leonardo Saboia-Vahia, Elisa Cupolillo, José Batista de Jesus, Roque P. de Almeida, Gabriel Padrón, Rubem Menna-Barreto, Patricia Cuervo
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Antioxidants
Subjects:
<i>Leishmania braziliensis</i>
nitric oxide resistance
American Tegumentary Leishmaniasis (ATL)
nitrosative stress
reactive oxygen species
reactive nitrogen species
Online Access:https://www.mdpi.com/2076-3921/11/2/277

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https://www.mdpi.com/2076-3921/11/2/277

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