An Oncolytic Adenovirus Encoding SA-4-1BBL Adjuvant Fused to HPV-16 E7 Antigen Produces a Specific Antitumor Effect in a Cancer Mouse Model

An Oncolytic Adenovirus Encoding SA-4-1BBL Adjuvant Fused to HPV-16 E7 Antigen Produces a Specific Antitumor Effect in a Cancer Mouse Model

Human papillomaviruses (HPVs) are responsible for about 25% of cancer cases worldwide. HPV-16 E7 antigen is a tumor-associated antigen (TAA) commonly expressed in HPV-induced tumors; however, it has low immunogenicity. The interaction of 4-1BBL with its receptor induces pleiotropic effects on innate...

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Bibliographic Details
Main Authors: Alejandra G. Martinez-Perez, Jose J. Perez-Trujillo, Rodolfo Garza-Morales, Norma E. Ramirez-Avila, Maria J. Loera-Arias, Jorge G. Gomez-Gutierrez, Odila Saucedo-Cardenas, Aracely Garcia-Garcia, Humberto Rodriguez-Rocha, Roberto Montes-de-Oca-Luna
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Vaccines
Subjects:
4-1BBL
cancer vaccines
oncolytic virus
HPV-16 antigen
Online Access:https://www.mdpi.com/2076-393X/9/2/149

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https://www.mdpi.com/2076-393X/9/2/149

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