Alternative Spliceosome Assembly Pathways Revealed by Single-Molecule Fluorescence Microscopy

Alternative Spliceosome Assembly Pathways Revealed by Single-Molecule Fluorescence Microscopy

Removal of introns from nascent transcripts (pre-mRNAs) by the spliceosome is an essential step in eukaryotic gene expression. Previous studies have suggested that the earliest steps in spliceosome assembly in yeast are highly ordered and the stable recruitment of U1 small nuclear ribonucleoprotein...

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Bibliographic Details
Main Authors: Inna Shcherbakova, Aaron A. Hoskins, Larry J. Friedman, Victor Serebrov, Ivan R. Corrêa, Jr., Ming-Qun Xu, Jeff Gelles, Melissa J. Moore
Format: Article
Language:English
Published: Elsevier 2013-10-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124713004671

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http://www.sciencedirect.com/science/article/pii/S2211124713004671

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