Formulating Resveratrol and Melatonin Self-Nanoemulsifying Drug Delivery Systems (SNEDDS) for Ocular Administration Using Design of Experiments

Formulating Resveratrol and Melatonin Self-Nanoemulsifying Drug Delivery Systems (SNEDDS) for Ocular Administration Using Design of Experiments

Recent studies have demonstrated that Sirtuin-1 (SIRT-1)-activating molecules exert a protective role in degenerative ocular diseases. However, these molecules hardly reach the back of the eye due to poor solubility in aqueous environments and low bioavailability after topical application on the eye...

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Bibliographic Details
Main Authors: Elide Zingale, Angela Bonaccorso, Agata Grazia D’Amico, Rosamaria Lombardo, Velia D’Agata, Jarkko Rautio, Rosario Pignatello
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Pharmaceutics
Subjects:
SNEDDS
ocular delivery
SIRT-1
stability
experimental design
surfactants
Online Access:https://www.mdpi.com/1999-4923/16/1/125

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