IL-17 suppresses the therapeutic activity of cancer vaccines through the inhibition of CD8+ T-cell responses

IL-17 suppresses the therapeutic activity of cancer vaccines through the inhibition of CD8+ T-cell responses

Antitumor immunity is mediated by Th1 CD4+ and CD8+ T lymphocytes, which induce tumor-specific cytolysis, whereas Th17 CD4+ T cells have been described to promote tumor growth. Here, we explored the influence of IL-17 on the ability of therapeutic vaccines to induce the rejection of tumors in mice u...

Full description

Bibliographic Details
Main Authors: Gilles Dadaglio, Catherine Fayolle, Marine Oberkampf, Alexandre Tang, Francesc Rudilla, Isabelle Couillin, Eirik A. Torheim, Pierre Rosenbaum, Claude Leclerc
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:OncoImmunology
Subjects:
tumor immunity
th17 cells
il-17
cytotoxic t cells
neutrophils
Online Access:http://dx.doi.org/10.1080/2162402X.2020.1758606

Internet

http://dx.doi.org/10.1080/2162402X.2020.1758606

Similar Items