Tumoral acidosis promotes adipose tissue depletion by fostering adipocyte lipolysis

Tumoral acidosis promotes adipose tissue depletion by fostering adipocyte lipolysis

Objective: Tumour progression drives profound alterations in host metabolism, such as adipose tissue depletion, an early event of cancer cachexia. As fatty acid consumption by cancer cells increases upon acidosis of the tumour microenvironment, we reasoned that fatty acids derived from distant adipo...

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Bibliographic Details
Main Authors: Camille Lefevre, Morgane M. Thibaut, Audrey Loumaye, Jean-Paul Thissen, Audrey M. Neyrinck, Benoit Navez, Nathalie M. Delzenne, Olivier Feron, Laure B. Bindels
Format: Article
Language:English
Published: Elsevier 2024-05-01
Series:Molecular Metabolism
Subjects:
Tumor acidosis
Adipose tissue
Lipolysis
Adipocytes
Cancer cachexia
Beta-glucuronidase
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877824000619

Internet

http://www.sciencedirect.com/science/article/pii/S2212877824000619

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