MicroRNA-195-5p Downregulation Inhibits Endothelial Mesenchymal Transition and Myocardial Fibrosis in Diabetic Cardiomyopathy by Targeting Smad7 and Inhibiting Transforming Growth Factor Beta 1-Smads-Snail Pathway

MicroRNA-195-5p Downregulation Inhibits Endothelial Mesenchymal Transition and Myocardial Fibrosis in Diabetic Cardiomyopathy by Targeting Smad7 and Inhibiting Transforming Growth Factor Beta 1-Smads-Snail Pathway

Diabetic cardiomyopathy (DCM) is a complication of diabetes mellitus, which is associated with fibrosis and microRNAs (miRs). This study estimated the mechanism of miR-195-5p in endothelial mesenchymal transition (EndMT) and myocardial fibrosis in DCM. After the establishment of DCM rat models, miR-...

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Bibliographic Details
Main Authors: Huaisheng Ding, Jianhui Yao, Hongxiang Xie, Chengyu Wang, Jing Chen, Kaiyong Wei, Yangyang Ji, Lihong Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Physiology
Subjects:
diabetic cardiomyopathy
miR-195-5p
TGF-β1-smads-snail pathway
smad7
endothelial mesenchymal transition
myocardial fibrosis
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.709123/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2021.709123/full

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