MicroRNA-195-5p Downregulation Inhibits Endothelial Mesenchymal Transition and Myocardial Fibrosis in Diabetic Cardiomyopathy by Targeting Smad7 and Inhibiting Transforming Growth Factor Beta 1-Smads-Snail Pathway

MicroRNA-195-5p Downregulation Inhibits Endothelial Mesenchymal Transition and Myocardial Fibrosis in Diabetic Cardiomyopathy by Targeting Smad7 and Inhibiting Transforming Growth Factor Beta 1-Smads-Snail Pathway

Diabetic cardiomyopathy (DCM) is a complication of diabetes mellitus, which is associated with fibrosis and microRNAs (miRs). This study estimated the mechanism of miR-195-5p in endothelial mesenchymal transition (EndMT) and myocardial fibrosis in DCM. After the establishment of DCM rat models, miR-...

Full description

Bibliographic Details
Main Authors:	Huaisheng Ding, Jianhui Yao, Hongxiang Xie, Chengyu Wang, Jing Chen, Kaiyong Wei, Yangyang Ji, Lihong Liu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-09-01
Series:	Frontiers in Physiology
Subjects:	diabetic cardiomyopathy miR-195-5p TGF-β1-smads-snail pathway smad7 endothelial mesenchymal transition myocardial fibrosis
Online Access:	https://www.frontiersin.org/articles/10.3389/fphys.2021.709123/full

Similar Items

Investigation of SMAD3 and SMAD4 Genes Expression in CML Patients and K562 Cell Line
by: T Mahdloo, et al.
Published: (2023-04-01)

YAP/TAZ regulates TGF-β/Smad3 signaling by induction of Smad7 via AP-1 in human skin dermal fibroblasts
by: Zhaoping Qin, et al.
Published: (2018-04-01)

Downregulated MicroRNA-195 in the Bicuspid Aortic Valve Promotes Calcification of Valve Interstitial Cells via Targeting SMAD7
by: Junjie Du, et al.
Published: (2017-11-01)

The role of green peas protein hydrolysate in TGF/SMAD signaling to prevent renal fibrosis
by: Meilinah Hidayat, et al.
Published: (2022-06-01)

Tyrosine hydroxylase inhibits HCC progression by downregulating TGFβ/Smad signaling
by: Guoqian Liu, et al.
Published: (2024-04-01)

Inhibitory effects of oxymatrine on hepatic stellate cells activation through TGF-β/miR-195/Smad signaling pathway
by: Li-Ying Song, et al.
Published: (2019-06-01)

Inhibition of tumor invasion and metastasis by targeting TGF-β-Smad-MMP2 pathway with Asiatic acid and Naringenin
by: Guang-Yu Lian, et al.
Published: (2021-03-01)

Tranilast Inhibits Pulmonary Fibrosis by Suppressing TGFβ/SMAD2 Pathway
by: Kato M, et al.
Published: (2020-10-01)

Association between Altered Expression and Genetic Variations of Transforming Growth Factor β-Smad Pathway with Chronic Myeloid Leukemia
by: Yogender Shokeen, et al.
Published: (2018-01-01)

Baicalin protects against renal interstitial fibrosis in mice by inhibiting the TGF-β/Smad signalling pathway
by: Hui Wang, et al.
Published: (2022-12-01)

TGF-β/Smad Signalling in Neurogenesis: Implications for Neuropsychiatric Diseases
by: Lih-Fhung Hiew, et al.
Published: (2021-06-01)

Regulation of TGF-β Superfamily Signaling by SMAD Mono-Ubiquitination
by: Feng Xie, et al.
Published: (2014-10-01)

Ellagic Acid Inhibits TGFβ1/Smad-Induced Renal Fibrosis in Diabetic Kidney Injury
by: Ozkan Gorgulu, et al.
Published: (2022-12-01)

Role of TGF-β/Smad Signaling Pathway-Related Proteins in Clinicopathological Features and Prognosis and Survival of Patients with Nasopharyngeal Carcinoma
by: Yanwei Rao, et al.
Published: (2021-03-01)

Targeting SMAD-Dependent Signaling: Considerations in Epithelial and Mesenchymal Solid Tumors
by: Farhana Runa, et al.
Published: (2024-03-01)

A study of Smad4, Smad6 and Smad7 in Surgically Resected Samples of Pancreatic Ductal Adenocarcinoma and Their Correlation with Clinicopathological Parameters and Patient Survival
by: Singh Puneet, et al.
Published: (2011-12-01)

Phospho-Smad3 signaling is predictive biomarker for hepatocellular carcinoma risk assessment in primary biliary cholangitis patients
by: Naohiro Nakamura, et al.
Published: (2021-12-01)

MicroRNA-497 induced by Clonorchis sinensis enhances the TGF-β/Smad signaling pathway to promote hepatic fibrosis by targeting Smad7
by: Qian-Yang Zhou, et al.
Published: (2021-09-01)

Differential Role of Smad2 and Smad3 in the Acquisition of an Endovascular Trophoblast-Like Phenotype and Preeclampsia
by: Jelena Brkić, et al.
Published: (2020-07-01)

Neoagarooligosaccharide Protects against Hepatic Fibrosis via Inhibition of TGF-β/Smad Signaling Pathway
by: Ji Hye Yang, et al.
Published: (2021-02-01)

SEPHS1 promotes SMAD2/3/4 expression and hepatocellular carcinoma cells invasion
by: Shu Yang, et al.
Published: (2021-02-01)

Salvianolic acid B ameliorates myocardial fibrosis in diabetic cardiomyopathy by deubiquitinating Smad7
by: Hong Luo, et al.
Published: (2023-12-01)

Apigenin protects myocardium by inhibiting the TGF-β1-mediated Smad signaling transduction pathway in acute myocardial infarcted rats
by: Ziliang Wang, et al.
Published: (2017-03-01)

Smad2/3 Activation Regulates Smad1/5/8 Signaling via a Negative Feedback Loop to Inhibit 3T3-L1 Adipogenesis
by: Senem Aykul, et al.
Published: (2021-08-01)

Expression analysis of the TGF-β/SMAD target genes in adenocarcinoma of esophagogastric junction
by: Peng Defeng, et al.
Published: (2016-01-01)

Sinomenine Relieves Airway Remodeling By Inhibiting Epithelial-Mesenchymal Transition Through Downregulating TGF-β1 and Smad3 Expression In Vitro and In Vivo
by: Hongjuan He, et al.
Published: (2021-11-01)

Analysis of the SMAD4 gene in asthma
by: Miletic Aleksandra, et al.
Published: (2014-12-01)

Assessment of the Role of Selected SMAD3 and SMAD4 Genes Polymorphisms in the Development of Colorectal Cancer: Preliminary Research
by: Wosiak A, et al.
Published: (2021-01-01)

MicroRNA-527 inhibits TGF-β/SMAD induced epithelial-mesenchymal transition via downregulating SULF2 expression in non-small-cell lung cancer
by: Wei Huo, et al.
Published: (2019-05-01)

The Upregulation of Caffeic Acid Phenethyl Ester on Growth Differentiation Factor 15 Inhibits Transforming Growth Factor β/Smad Signaling in Bladder Carcinoma Cells
by: Chen-Pang Hou, et al.
Published: (2022-07-01)

Resveratrol ameliorates myocardial fibrosis by regulating Sirt1/Smad3 deacetylation pathway in rat model with dilated cardiomyopathy
by: Qingquan Chen, et al.
Published: (2022-01-01)

Effect of aging on the formation and growth of colonic epithelial organoids by changes in cell cycle arrest through TGF-β-Smad3 signaling
by: Min Kyoung Jo, et al.
Published: (2023-07-01)

SMAD4 and the TGFβ Pathway in Patients with Pancreatic Ductal Adenocarcinoma
by: Julie Dardare, et al.
Published: (2020-05-01)

Endometrial PTEN Deficiency Leads to SMAD2/3 Nuclear Translocation
by: Núria Eritja, et al.
Published: (2021-10-01)

Qishen Yiqi Dripping Pill Protects Against Diabetic Nephropathy by Inhibiting the Wnt/β-Catenin and Transforming Growth Factor-β/Smad Signaling Pathways in Rats
by: Qian Zhang, et al.
Published: (2021-02-01)

Expression of pelvic organ prolapse-related protein fibulin-5, TGFβ, and Smad2/3 in Uyghur women of Xinjiang
by: Shaadaiti Wufuer, et al.
Published: (2021-04-01)

Differential regulation of TGF-β/Smad signaling in hepatic stallate cells between acute and chronic liver injuries
by: Katsunori eYoshida, et al.
Published: (2012-03-01)

SMADS-Mediate Molecular Mechanisms in Sjögren’s Syndrome
by: Margherita Sisto, et al.
Published: (2021-03-01)

Expression and Polymorphisms of <i>SMAD1</i>, <i>SMAD2</i> and <i>SMAD3</i> Genes and Their Association with Litter Size in Tibetan Sheep (<i>Ovis aries</i>)
by: Mingming Li, et al.
Published: (2022-12-01)

GPR37 promotes the malignancy of lung adenocarcinoma via TGF-β/Smad pathway
by: Wang Jian, et al.
Published: (2020-12-01)