Sperm chromatin structure assay (SCSA®) and flow cytometry-assisted TUNEL assay provide a concordant assessment of sperm DNA fragmentation as a function of age in a large cohort of approximately 10,000 patients

Sperm chromatin structure assay (SCSA®) and flow cytometry-assisted TUNEL assay provide a concordant assessment of sperm DNA fragmentation as a function of age in a large cohort of approximately 10,000 patients

Abstract Background Sperm DNA integrity is increasingly seen as a critical characteristic determining reproductive success, both in natural reproduction and in assisted reproductive technologies (ART). Despite this awareness, sperm DNA and nuclear integrity tests are still not part of routine examin...

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Bibliographic Details
Main Authors: Paria Behdarvandian, Ali Nasr-Esfahani, Marziyeh Tavalaee, Kosar Pashaei, Nushin Naderi, Zahra Darmishonnejad, Jorge Hallak, Robert J. Aitken, Parviz Gharagozloo, Joël R. Drevet, Mohammad Hossein Nasr-Esfahani
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Basic and Clinical Andrology
Subjects:
Spermatozoa
Ageing
DNA fragmentation
Male fertility
Reproductive health
Online Access:https://doi.org/10.1186/s12610-023-00208-9

Internet

https://doi.org/10.1186/s12610-023-00208-9

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