Prolonged administration of total glucosides of paeony improves intestinal immune imbalance and epithelial barrier damage in collagen-induced arthritis rats based on metabolomics-network pharmacology integrated analysis

Prolonged administration of total glucosides of paeony improves intestinal immune imbalance and epithelial barrier damage in collagen-induced arthritis rats based on metabolomics-network pharmacology integrated analysis

Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by synovial inflammation and joint damage with complex pathological mechanisms. In recent years, many studies have shown that the dysregulation of intestinal mucosal immunity and the damage of the epithelial barrier are...

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Bibliographic Details
Main Authors: Rui Xu, Jine Peng, Zhe Ma, Kaili Xie, Meijing Li, Qi Wang, Xiaomeng Guo, Nan Nan, Sihui Wang, Jing Li, Jingjing Xu, Muxin Gong
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Pharmacology
Subjects:
rheumatoid arthritis
total glucosides of paeony
collagen-induced arthritis
metabolomics
network pharmacology
intestinal mucosal immunity
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1187797/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1187797/full

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