Electrophysiological evidence of increased glycine receptor-mediated phasic and tonic inhibition by blockade of glycine transporters in spinal superficial dorsal horn neurons of adult mice

Electrophysiological evidence of increased glycine receptor-mediated phasic and tonic inhibition by blockade of glycine transporters in spinal superficial dorsal horn neurons of adult mice

To understand the synaptic and/or extrasynaptic mechanisms underlying pain relief by blockade of glycine transporter subtypes GlyT1 and GlyT2, whole-cell recordings were made from dorsal horn neurons in spinal slices from adult mice, and the effects of NFPS and ALX-1393, selective GlyT1 and GlyT2 in...

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Bibliographic Details
Main Authors: Misa Oyama, Seiya Kuraoka, Shun Watanabe, Takashi Iwai, Mitsuo Tanabe
Format: Article
Language:English
Published: Elsevier 2017-03-01
Series:Journal of Pharmacological Sciences
Subjects:
Patch clamp
Inhibitory postsynaptic synaptic currents
Spinal cord
Strychnine-sensitive glycine receptor
Glycine transporter
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861317300270

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http://www.sciencedirect.com/science/article/pii/S1347861317300270

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