oriD structure controls RepD initiation during rolling-circle replication

Abstract Bacterial antibiotic resistance is often carried by circular DNA plasmids that are copied separately from the genomic DNA and can be passed to other bacteria, spreading the resistance. The chloramphenicol-resistance plasmid pC221 from Staphylococcus aureus is duplicated by a process called...

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Bibliographic Details
Main Authors: Algirdas Toleikis, Martin R. Webb, Justin E. Molloy
Format: Article
Language:English
Published: Nature Portfolio 2018-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-18817-6