SCP2 mediates the transport of lipid hydroperoxides to mitochondria in chondrocyte ferroptosis

SCP2 mediates the transport of lipid hydroperoxides to mitochondria in chondrocyte ferroptosis

Abstract Sterol carrier protein 2 (SCP2) is highly expressed in human osteoarthritis (OA) cartilage, accompanied by ferroptosis hallmarks, especially the accumulation of lipid hydroperoxides (LPO). However, the role of SCP2 in chondrocyte ferroptosis remains unexplored. Here, we identify that SCP2 t...

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Bibliographic Details
Main Authors: Tianming Dai, Xiang Xue, Jian Huang, Zhenyu Yang, Pengfei Xu, Min Wang, Wuyan Xu, Zhencheng Feng, Weicong Zhu, Yangyang Xu, Junyan Chen, Siming Li, Qingqi Meng
Format: Article
Language:English
Published: Nature Publishing Group 2023-07-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-023-01522-x

Internet

https://doi.org/10.1038/s41420-023-01522-x

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