"Negative vaccination" by specific CD4 T cell tolerisation enhances virus-specific protective antibody responses.

"Negative vaccination" by specific CD4 T cell tolerisation enhances virus-specific protective antibody responses.

BACKGROUND: Cooperation of CD4+ T helper cells with specific B cells is crucial for protective vaccination against pathogens by inducing long-lived neutralizing antibody responses. During infection with persistence-prone viruses, prolonged virus replication correlates with low neutralizing antibody...

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Bibliographic Details
Main Authors: Karl S Lang, Ahmed N Hegazy, Philipp A Lang, Bruno Eschli, Max Löhning, Hans Hengartner, Rolf M Zinkernagel, Mike Recher
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2048666?pdf=render

Internet

http://europepmc.org/articles/PMC2048666?pdf=render

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