Polysaccharides from Agaricus blazei Murrill ameliorate dextran sulfate sodium-induced colitis via attenuating intestinal barrier dysfunction

Ulcerative colitis (UC) is characterized by chronic relapsing and persistent inflammation that mainly affects the colon. The purpose of this study was to investigate the therapeutic effect of Agaricus blazei Murrill polysaccharides (ABP) or selenium-enriched Agaricus blazei Murrill polysaccharides (...

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Main Authors: Yukun Zhang, Feng Lu, Hang Zhang, Yuwei Ye, Penghu Liu, Dongmei Lin, Hong Zhou, Min Li, Baoxue Yang
Format: Article
Language:English
Published: Elsevier 2022-05-01
Series:Journal of Functional Foods
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464622001426
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author Yukun Zhang
Feng Lu
Hang Zhang
Yuwei Ye
Penghu Liu
Dongmei Lin
Hong Zhou
Min Li
Baoxue Yang
author_facet Yukun Zhang
Feng Lu
Hang Zhang
Yuwei Ye
Penghu Liu
Dongmei Lin
Hong Zhou
Min Li
Baoxue Yang
author_sort Yukun Zhang
collection DOAJ
description Ulcerative colitis (UC) is characterized by chronic relapsing and persistent inflammation that mainly affects the colon. The purpose of this study was to investigate the therapeutic effect of Agaricus blazei Murrill polysaccharides (ABP) or selenium-enriched Agaricus blazei Murrill polysaccharides (ABP-Se) on UC. UC mouse model was established by 2.5% dextran sulfate sodium (DSS). Markers for colonic barrier functions, cytokines and oxidative stress were measured. The experimental results showed that ABP and ABP-Se significantly alleviated UC-related symptoms, including weight loss, colon shorten, and disease activity index scores. Meanwhile, ABP and ABP-Se significantly promoted tight junction proteins and mucus content, and decreased inflammation and oxidative stress. Moreover, ABP-Se exhibited a better anti-oxidative ability compared to ABP. The experimental results suggest that ABP and ABP-Se relieve DSS-induced colitis via reducing inflammatory cytokines and oxidative stress, and preventing colonic barrier damage. This study suggests a promising therapeutic effect of mushrooms-derived polysaccharides on UC.
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spelling doaj.art-524d9e28c3a5458899a4cfb9e8efaca22022-12-22T02:02:37ZengElsevierJournal of Functional Foods1756-46462022-05-0192105072Polysaccharides from Agaricus blazei Murrill ameliorate dextran sulfate sodium-induced colitis via attenuating intestinal barrier dysfunctionYukun Zhang0Feng Lu1Hang Zhang2Yuwei Ye3Penghu Liu4Dongmei Lin5Hong Zhou6Min Li7Baoxue Yang8State Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing 100191, ChinaState Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing 100191, ChinaState Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing 100191, ChinaState Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing 100191, ChinaNational Engineering Research Center of JUNCAO Technology, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, ChinaNational Engineering Research Center of JUNCAO Technology, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, ChinaState Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing 100191, ChinaState Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing 100191, ChinaState Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing 100191, China; Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing 100191, China; Corresponding author at: State Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.Ulcerative colitis (UC) is characterized by chronic relapsing and persistent inflammation that mainly affects the colon. The purpose of this study was to investigate the therapeutic effect of Agaricus blazei Murrill polysaccharides (ABP) or selenium-enriched Agaricus blazei Murrill polysaccharides (ABP-Se) on UC. UC mouse model was established by 2.5% dextran sulfate sodium (DSS). Markers for colonic barrier functions, cytokines and oxidative stress were measured. The experimental results showed that ABP and ABP-Se significantly alleviated UC-related symptoms, including weight loss, colon shorten, and disease activity index scores. Meanwhile, ABP and ABP-Se significantly promoted tight junction proteins and mucus content, and decreased inflammation and oxidative stress. Moreover, ABP-Se exhibited a better anti-oxidative ability compared to ABP. The experimental results suggest that ABP and ABP-Se relieve DSS-induced colitis via reducing inflammatory cytokines and oxidative stress, and preventing colonic barrier damage. This study suggests a promising therapeutic effect of mushrooms-derived polysaccharides on UC.http://www.sciencedirect.com/science/article/pii/S1756464622001426Ulcerative colitisPolysaccharidesAgaricus blazei MurrillSeleniumColonic barrier
spellingShingle Yukun Zhang
Feng Lu
Hang Zhang
Yuwei Ye
Penghu Liu
Dongmei Lin
Hong Zhou
Min Li
Baoxue Yang
Polysaccharides from Agaricus blazei Murrill ameliorate dextran sulfate sodium-induced colitis via attenuating intestinal barrier dysfunction
Journal of Functional Foods
Ulcerative colitis
Polysaccharides
Agaricus blazei Murrill
Selenium
Colonic barrier
title Polysaccharides from Agaricus blazei Murrill ameliorate dextran sulfate sodium-induced colitis via attenuating intestinal barrier dysfunction
title_full Polysaccharides from Agaricus blazei Murrill ameliorate dextran sulfate sodium-induced colitis via attenuating intestinal barrier dysfunction
title_fullStr Polysaccharides from Agaricus blazei Murrill ameliorate dextran sulfate sodium-induced colitis via attenuating intestinal barrier dysfunction
title_full_unstemmed Polysaccharides from Agaricus blazei Murrill ameliorate dextran sulfate sodium-induced colitis via attenuating intestinal barrier dysfunction
title_short Polysaccharides from Agaricus blazei Murrill ameliorate dextran sulfate sodium-induced colitis via attenuating intestinal barrier dysfunction
title_sort polysaccharides from agaricus blazei murrill ameliorate dextran sulfate sodium induced colitis via attenuating intestinal barrier dysfunction
topic Ulcerative colitis
Polysaccharides
Agaricus blazei Murrill
Selenium
Colonic barrier
url http://www.sciencedirect.com/science/article/pii/S1756464622001426
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