Polysaccharides from Agaricus blazei Murrill ameliorate dextran sulfate sodium-induced colitis via attenuating intestinal barrier dysfunction
Ulcerative colitis (UC) is characterized by chronic relapsing and persistent inflammation that mainly affects the colon. The purpose of this study was to investigate the therapeutic effect of Agaricus blazei Murrill polysaccharides (ABP) or selenium-enriched Agaricus blazei Murrill polysaccharides (...
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Elsevier
2022-05-01
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Series: | Journal of Functional Foods |
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Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464622001426 |
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author | Yukun Zhang Feng Lu Hang Zhang Yuwei Ye Penghu Liu Dongmei Lin Hong Zhou Min Li Baoxue Yang |
author_facet | Yukun Zhang Feng Lu Hang Zhang Yuwei Ye Penghu Liu Dongmei Lin Hong Zhou Min Li Baoxue Yang |
author_sort | Yukun Zhang |
collection | DOAJ |
description | Ulcerative colitis (UC) is characterized by chronic relapsing and persistent inflammation that mainly affects the colon. The purpose of this study was to investigate the therapeutic effect of Agaricus blazei Murrill polysaccharides (ABP) or selenium-enriched Agaricus blazei Murrill polysaccharides (ABP-Se) on UC. UC mouse model was established by 2.5% dextran sulfate sodium (DSS). Markers for colonic barrier functions, cytokines and oxidative stress were measured. The experimental results showed that ABP and ABP-Se significantly alleviated UC-related symptoms, including weight loss, colon shorten, and disease activity index scores. Meanwhile, ABP and ABP-Se significantly promoted tight junction proteins and mucus content, and decreased inflammation and oxidative stress. Moreover, ABP-Se exhibited a better anti-oxidative ability compared to ABP. The experimental results suggest that ABP and ABP-Se relieve DSS-induced colitis via reducing inflammatory cytokines and oxidative stress, and preventing colonic barrier damage. This study suggests a promising therapeutic effect of mushrooms-derived polysaccharides on UC. |
first_indexed | 2024-12-10T04:15:07Z |
format | Article |
id | doaj.art-524d9e28c3a5458899a4cfb9e8efaca2 |
institution | Directory Open Access Journal |
issn | 1756-4646 |
language | English |
last_indexed | 2024-12-10T04:15:07Z |
publishDate | 2022-05-01 |
publisher | Elsevier |
record_format | Article |
series | Journal of Functional Foods |
spelling | doaj.art-524d9e28c3a5458899a4cfb9e8efaca22022-12-22T02:02:37ZengElsevierJournal of Functional Foods1756-46462022-05-0192105072Polysaccharides from Agaricus blazei Murrill ameliorate dextran sulfate sodium-induced colitis via attenuating intestinal barrier dysfunctionYukun Zhang0Feng Lu1Hang Zhang2Yuwei Ye3Penghu Liu4Dongmei Lin5Hong Zhou6Min Li7Baoxue Yang8State Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing 100191, ChinaState Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing 100191, ChinaState Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing 100191, ChinaState Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing 100191, ChinaNational Engineering Research Center of JUNCAO Technology, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, ChinaNational Engineering Research Center of JUNCAO Technology, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, ChinaState Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing 100191, ChinaState Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing 100191, ChinaState Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing 100191, China; Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing 100191, China; Corresponding author at: State Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.Ulcerative colitis (UC) is characterized by chronic relapsing and persistent inflammation that mainly affects the colon. The purpose of this study was to investigate the therapeutic effect of Agaricus blazei Murrill polysaccharides (ABP) or selenium-enriched Agaricus blazei Murrill polysaccharides (ABP-Se) on UC. UC mouse model was established by 2.5% dextran sulfate sodium (DSS). Markers for colonic barrier functions, cytokines and oxidative stress were measured. The experimental results showed that ABP and ABP-Se significantly alleviated UC-related symptoms, including weight loss, colon shorten, and disease activity index scores. Meanwhile, ABP and ABP-Se significantly promoted tight junction proteins and mucus content, and decreased inflammation and oxidative stress. Moreover, ABP-Se exhibited a better anti-oxidative ability compared to ABP. The experimental results suggest that ABP and ABP-Se relieve DSS-induced colitis via reducing inflammatory cytokines and oxidative stress, and preventing colonic barrier damage. This study suggests a promising therapeutic effect of mushrooms-derived polysaccharides on UC.http://www.sciencedirect.com/science/article/pii/S1756464622001426Ulcerative colitisPolysaccharidesAgaricus blazei MurrillSeleniumColonic barrier |
spellingShingle | Yukun Zhang Feng Lu Hang Zhang Yuwei Ye Penghu Liu Dongmei Lin Hong Zhou Min Li Baoxue Yang Polysaccharides from Agaricus blazei Murrill ameliorate dextran sulfate sodium-induced colitis via attenuating intestinal barrier dysfunction Journal of Functional Foods Ulcerative colitis Polysaccharides Agaricus blazei Murrill Selenium Colonic barrier |
title | Polysaccharides from Agaricus blazei Murrill ameliorate dextran sulfate sodium-induced colitis via attenuating intestinal barrier dysfunction |
title_full | Polysaccharides from Agaricus blazei Murrill ameliorate dextran sulfate sodium-induced colitis via attenuating intestinal barrier dysfunction |
title_fullStr | Polysaccharides from Agaricus blazei Murrill ameliorate dextran sulfate sodium-induced colitis via attenuating intestinal barrier dysfunction |
title_full_unstemmed | Polysaccharides from Agaricus blazei Murrill ameliorate dextran sulfate sodium-induced colitis via attenuating intestinal barrier dysfunction |
title_short | Polysaccharides from Agaricus blazei Murrill ameliorate dextran sulfate sodium-induced colitis via attenuating intestinal barrier dysfunction |
title_sort | polysaccharides from agaricus blazei murrill ameliorate dextran sulfate sodium induced colitis via attenuating intestinal barrier dysfunction |
topic | Ulcerative colitis Polysaccharides Agaricus blazei Murrill Selenium Colonic barrier |
url | http://www.sciencedirect.com/science/article/pii/S1756464622001426 |
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