Comparing HD knockin pigs and mice reveals the pathological role of IL-17

Comparing HD knockin pigs and mice reveals the pathological role of IL-17

Summary: Our previous work has established a knockin (KI) pig model of Huntington’s disease (HD) that can replicate the typical pathological features of HD, including selective striatal neuronal loss, reactive gliosis, and axonal degeneration. However, HD KI mice exhibit milder neuropathological phe...

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Bibliographic Details
Main Authors: Qingqing Jia, Dazhang Bai, Xiao Zheng, Longhong Zhu, Kaili Ou, Xiang Wang, Huichun Tong, Yiran Zhang, Jing Wang, Jun Zeng, Sen Yan, Shihua Li, Xiao-Jiang Li, Peng Yin
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Cell Reports
Subjects:
CP: Neuroscience
CP: Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723014559

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http://www.sciencedirect.com/science/article/pii/S2211124723014559

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