Determination of steroid hydroxylation specificity of an industrial strain Aspergillus ochraceus TCCC41060 by cytochrome P450 gene CYP68J5

Determination of steroid hydroxylation specificity of an industrial strain Aspergillus ochraceus TCCC41060 by cytochrome P450 gene CYP68J5

Abstract Purpose The use of Aspergillus ochraceus TCCC41060 for synthesis of 11α-OH-ethylgonendione, an important intermediate for synthesis of desogestrel-a major ingredient of the “third-generation” oral contraceptives, is hampered by its low regioselectivity of hydroxylation. In the present study...

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Bibliographic Details
Main Authors: Xue Wang, Xingwei Yang, Xi Jia, Peng Jin, Zhengxiang Wang, Fuping Lu, Xiaoguang Liu
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Annals of Microbiology
Subjects:
Aspergillus ochraceus
Steroid
Hydroxylase
Cytochrome P450
D-ethylgonendione
Glucocorticoids
Online Access:https://doi.org/10.1186/s13213-020-01577-6

Internet

https://doi.org/10.1186/s13213-020-01577-6

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