Relevance of Abnormal KCNN1 Expression and Osmotic Hypersensitivity in Ewing Sarcoma

Relevance of Abnormal KCNN1 Expression and Osmotic Hypersensitivity in Ewing Sarcoma

Ewing sarcoma (EwS) is a rare and highly malignant bone tumor occurring mainly in childhood and adolescence. Physiologically, the bone is a central hub for Ca<sup>2+</sup> homeostasis, which is severely disturbed by osteolytic processes in EwS. Therefore, we aimed to investigate how ion...

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Bibliographic Details
Main Authors: Sebastian Fuest, Christoph Post, Sebastian T. Balbach, Susanne Jabar, Ilka Neumann, Sandra Schimmelpfennig, Sarah Sargin, Elke Nass, Thomas Budde, Sareetha Kailayangiri, Bianca Altvater, Andreas Ranft, Wolfgang Hartmann, Uta Dirksen, Claudia Rössig, Albrecht Schwab, Zoltán Pethő
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Cancers
Subjects:
K<sub>Ca</sub>2.1 channel
Ewing sarcoma
GGAA microsatellite
regulatory volume decrease
Online Access:https://www.mdpi.com/2072-6694/14/19/4819

Internet

https://www.mdpi.com/2072-6694/14/19/4819

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