Synthesis of Highly Substituted Oxazoles through Iodine(III)-Mediated Reactions of Ketones with Nitriles

Synthesis of Highly Substituted Oxazoles through Iodine(III)-Mediated Reactions of Ketones with Nitriles

In the presence of trifluoromethanesulfonic acid (TfOH) or bis(trifluoromethane-sulfonyl)imide (Tf2NH), iodosobenzene (PhI=O) efficiently promoted the reactions of dicarbonyl compounds as well as monocarbonyl compounds with nitriles to give 2,4-disubstituted and 2,4,5-trisubstituted oxazole in a sin...

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Bibliographic Details
Main Authors: Yuji Hanzawa, Akio Saito, Nao Hyodo
Format: Article
Language:English
Published: MDPI AG 2012-09-01
Series:Molecules
Subjects:
single-step synthesis
iodine(III)
oxazole
ketone
nitrile
Online Access:http://www.mdpi.com/1420-3049/17/9/11046

Internet

http://www.mdpi.com/1420-3049/17/9/11046

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