Synthesis of Highly Substituted Oxazoles through Iodine(III)-Mediated Reactions of Ketones with Nitriles
In the presence of trifluoromethanesulfonic acid (TfOH) or bis(trifluoromethane-sulfonyl)imide (Tf2NH), iodosobenzene (PhI=O) efficiently promoted the reactions of dicarbonyl compounds as well as monocarbonyl compounds with nitriles to give 2,4-disubstituted and 2,4,5-trisubstituted oxazole in a sin...
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| Format: | Article |
| Language: | English |
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MDPI AG
2012-09-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/17/9/11046 |
| _version_ | 1828483285619048448 |
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| author | Yuji Hanzawa Akio Saito Nao Hyodo |
| author_facet | Yuji Hanzawa Akio Saito Nao Hyodo |
| author_sort | Yuji Hanzawa |
| collection | DOAJ |
| description | In the presence of trifluoromethanesulfonic acid (TfOH) or bis(trifluoromethane-sulfonyl)imide (Tf2NH), iodosobenzene (PhI=O) efficiently promoted the reactions of dicarbonyl compounds as well as monocarbonyl compounds with nitriles to give 2,4-disubstituted and 2,4,5-trisubstituted oxazole in a single step under the mild conditions. |
| first_indexed | 2024-12-11T08:33:32Z |
| format | Article |
| id | doaj.art-5254c62a65064c72ac694306b5d20452 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-11T08:33:32Z |
| publishDate | 2012-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-5254c62a65064c72ac694306b5d204522022-12-22T01:14:24ZengMDPI AGMolecules1420-30492012-09-01179110461105510.3390/molecules170911046Synthesis of Highly Substituted Oxazoles through Iodine(III)-Mediated Reactions of Ketones with NitrilesYuji HanzawaAkio SaitoNao HyodoIn the presence of trifluoromethanesulfonic acid (TfOH) or bis(trifluoromethane-sulfonyl)imide (Tf2NH), iodosobenzene (PhI=O) efficiently promoted the reactions of dicarbonyl compounds as well as monocarbonyl compounds with nitriles to give 2,4-disubstituted and 2,4,5-trisubstituted oxazole in a single step under the mild conditions.http://www.mdpi.com/1420-3049/17/9/11046single-step synthesisiodine(III)oxazoleketonenitrile |
| spellingShingle | Yuji Hanzawa Akio Saito Nao Hyodo Synthesis of Highly Substituted Oxazoles through Iodine(III)-Mediated Reactions of Ketones with Nitriles Molecules single-step synthesis iodine(III) oxazole ketone nitrile |
| title | Synthesis of Highly Substituted Oxazoles through Iodine(III)-Mediated Reactions of Ketones with Nitriles |
| title_full | Synthesis of Highly Substituted Oxazoles through Iodine(III)-Mediated Reactions of Ketones with Nitriles |
| title_fullStr | Synthesis of Highly Substituted Oxazoles through Iodine(III)-Mediated Reactions of Ketones with Nitriles |
| title_full_unstemmed | Synthesis of Highly Substituted Oxazoles through Iodine(III)-Mediated Reactions of Ketones with Nitriles |
| title_short | Synthesis of Highly Substituted Oxazoles through Iodine(III)-Mediated Reactions of Ketones with Nitriles |
| title_sort | synthesis of highly substituted oxazoles through iodine iii mediated reactions of ketones with nitriles |
| topic | single-step synthesis iodine(III) oxazole ketone nitrile |
| url | http://www.mdpi.com/1420-3049/17/9/11046 |
| work_keys_str_mv | AT yujihanzawa synthesisofhighlysubstitutedoxazolesthroughiodineiiimediatedreactionsofketoneswithnitriles AT akiosaito synthesisofhighlysubstitutedoxazolesthroughiodineiiimediatedreactionsofketoneswithnitriles AT naohyodo synthesisofhighlysubstitutedoxazolesthroughiodineiiimediatedreactionsofketoneswithnitriles |